hMOB3 Modulates MST1 Apoptotic Signaling and Supports Tumor Growth in Glioblastoma Multiforme
نویسندگان
چکیده
منابع مشابه
Molecular and Cellular Pathobiology hMOB3 Modulates MST1 Apoptotic Signaling and Supports Tumor Growth in Glioblastoma Multiforme
New therapeutic targets are needed that circumvent inherent therapeutic resistance of glioblastoma multiforme (GBM). Here, we report such a candidate target in the uncharacterized adaptor protein hMOB3, which we show is upregulated in GBM. In a search for its biochemical function, we found that hMOB3 specifically interacts with MST1 kinase in response to apoptotic stimuli and cell–cell contact....
متن کاملhMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.
New therapeutic targets are needed that circumvent inherent therapeutic resistance of glioblastoma multiforme (GBM). Here, we report such a candidate target in the uncharacterized adaptor protein hMOB3, which we show is upregulated in GBM. In a search for its biochemical function, we found that hMOB3 specifically interacts with MST1 kinase in response to apoptotic stimuli and cell-cell contact....
متن کاملhMOB 3 modulates MST 1 apoptotic signaling and supports tumor growth in 1 glioblastoma multiforme
Financial Support: Gongda Xue and Debora Schmitz-Rohmer are supported by the Swiss 11 National Science Foundation SNF 31003A_130838 and 31003A_138287, respectively. Christian 12 Hundsrucker is supported by Swiss Initiative in Systems Biology (Systems Biology IT). 13 Alexander Hergovich is a Wellcome Trust Research Career Development fellow (grant 14 090090/Z/09/Z). The FMI is supported by the N...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2014
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-13-3430